Psychiatrist Dr. Frasier Crane (Grammer) returns to his hometown of Seattle, Washington, following the end of his marriage and his life in Boston (as seen in Cheers). His plans for a new life as a bachelor are complicated when he is obliged to take in his father, retired police officer Martin (Mahoney), who is unable to live by himself after being shot in the line of duty. Frasier and Martin are joined by Daphne Moon (Leeves), Martin's eccentric English live-in physical therapist and caretaker, and Martin's dog Eddie (Moose). Frasier's younger brother Niles (Pierce), a fellow psychiatrist, frequently visits their apartment. Niles' infatuation with, and eventual love for Daphne—feelings which he does not confess to her openly until the final episode of the seventh season—form a complex story arc that spans the entire series. Frasier hosts a popular radio talk show on KACL[3] 780AM. While his producer Roz Doyle (Gilpin) is very different from Frasier in taste and temperament, over time they become very close friends. Frasier and his brother often visit the local coffee shop Café Nervosa, the scene of many of their comic adventures.

Source: Wikipedia.org