The Oprah Winfrey Show

The Oprah Winfrey Show (often simply referred to as Oprah or just O) is an American syndicated talk show, hosted and produced by its namesake Oprah Winfrey, and is the highest-rated talk show in American television history.[1] It is currently the longest-running daytime television talk show in the United States, having run nationally since September 8, 1986, for over 22 seasons and 3,724 episodes as of November 21, 2008. The show is renewed through 2011, but in a 2008 interview with Larry King, Oprah tearfully announced that in 2011, she will not renew her contract, thus ending the show.

Source: Wikipedia.org